Details Page for 2XRA

Antibody Structure Summary Page
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Antibody Name: IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HK20 FAB IN COMPLEX WITH A GP41 MIMETIC 5 - HELIX

[COMPLEX]

Summary Information

PDB ID 2XRA
Antigen MOLECULE: TRANSMEMBRANE PROTEIN GP41; FRAGMENT: 5 - HELIX INNER - CORE MIMETIC COMPRISED OF REPEATS OF RESIDUES 543 - 582 AND 625 - 662; ENGINEERED: YES; OTHER_DETAILS: SEQUENCE DERIVED FROM UNIPROT AC P04578 WHERE THREE REGIONS EACH EQUIVALENT TO AA 543 - 582 ARE INTERSPERSED BY TWO DIFFERENT REGIONS (EACH EQUIVALENT TO AA 625 - 662) . LINKERS GGSGG AND GSSGG JOIN THE REGIONS AND ALTERNATE STARTING WITH GGSGG. A METHIONINE INITIATES AND A TAIL CONTAINS GGHHHHHHG. CF\: ROOT ET AL, SCIENCE\: VOL. 291. NO. 5505,PP. 884 - 888,2001;
Complex Yes
Light Chain Class ?
Heavy Chain Class ?
Source HOMO SAPIENS

Structural Information

CDRs Length Sequence
L1 11 QASQDIRNHLN
L2 7 DASNLAT
L3 10 QHYDDLPRIT
H1 5 RLAMS
H2 17 GIMPIFDITNYAQKFQG
H3 13 ASYSSSSPYAFDI

Experimental Information

Experimental Method crystal
Resolution 2.30A
R-factor 23.91%
Fragment Type FAB
Deposition date 13-SEP-10